Chronotropic Incompetence Predicts Distance Walked in Six-Minute Walk Test in Heart Failure with Preserved Ejection Fraction

The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and heterogeneous. Chronotropic incompetence (CI) has emerged as a potential mechanism causally related to proxies of functional capacity impairment.1-4 Distance-walked in 6 minutes test (6-MWT), is a widely available and clinically useful parameter to assess submaximal aerobic capacity.5 In this work, we sought to evaluate whether CI is associated with 6-MWT beyond clinical, echocardiographic, laboratory, and CPET parameters in patients with stable symptomatic HFpEF (NYHA II-III).
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Research Letter Source Type: research