The impact of maternal asthma during pregnancy on fetal growth and development: a review.

The impact of maternal asthma during pregnancy on fetal growth and development: a review. Expert Rev Respir Med. 2020 Aug 21;: Authors: Meakin AS, Saif Z, Seedat N, Clifton VL Abstract INTRODUCTION: Asthma is a highly prevalent co-morbidity during pregnancy that can worsen as gestation progresses and is associated with several adverse perinatal outcomes. These adverse outcomes often result from uncontrolled asthma during pregnancy and acute asthma exacerbation that are associated with alterations in placental function and fetal growth. AREAS COVERED: This paper will discuss how maternal asthma in pregnancy affects fetal growth and development which may alter future offspring health. Changes in placental function occur in a sex specific manner in pregnancies complicated by asthma and result in differences in fetal growth and development which may influence child health. The follow up of children from mothers with asthma suggests they are at greater risk of developing asthma, have alterations in microvascular structure that may contribute to a future risk of cardiovascular disease and epigenetic modifications in immune cell function. The current evidence suggests that appropriately managed asthma during pregnancy results in normal fetal growth and development. EXPERT OPINION: Clinical management of asthma during pregnancy needs significant improvement to prevent adverse outcomes for the fetus. The key to improving maternal and fetal outcomes is thro...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

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Publication date: Available online 8 October 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Annelies L. Robijn, Daniel Barker, Peter G. Gibson, Warwick B. Giles, Vicki L. Clifton, Joerg Mattes, Michael J. Peek, Helen L. Barrett, Sean K. Seeho, Leonie K. Callaway, Alistair Abbott, John Attia, Peter A. Wark, Megan E. Jensen, Vanessa E. Murphy
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
This article reviews recent developments of asthma pharmacotherapy and provides emerging data on the safety of asthma controller medications and biological therapies in pregnancy. The authors highlight the clinical outcomes of asthma during pregnancy, and summarize emerging new data related to the influence of sex hormones and fetal sex on asthma severity. AREAS COVERED: This review of asthma pharmacotherapy during pregnancy examines the recent guidelines and reports the most pertinent publications on safety data and asthma management. EXPERT OPINION: Asthma management during pregnancy follows the same principles a...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
CONCLUSION: Higher PM2.5 during the first trimester of pregnancy and low CB vitamin D affected early onset persistent AD, and the most sensitive window was weeks 6-7 of gestation. Placental DNA methylation mediated this effect. PMID: 32971247 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
When a pregnant woman gained more than 33 pounds, the risk of childhood asthma or a food or drug allergy in offspring increased.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Weight Asthma Children and Childhood Eczema Hay Fever Pregnancy and Childbirth Source Type: news
Abstract Diets rich in saturated fats have become a staple globally. Fifty percent of women of childbearing age in the United States are obese or overweight, with diet being a significant contributor. There is increasing evidence of the impact of maternal high-fat diet on the offspring microbiome. Alterations of the neonatal microbiome have been shown to be associated with multiple morbidities, including the development of necrotizing enterocolitis, atopy, asthma, metabolic dysfunction, and hypertension among others. This review provides an overview of the recent studies and mechanisms being examined on how matern...
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Abstract OBJECTIVE: Exposome encompasses all human environmental exposures from conception onwards. The impact of environmental exposures is greatest in critical stages of life including fetal and early childhood. Birth cohorts provide a good study setting to assess exposome in the sensitive periods of life. Here, we review birth cohorts with an exposomic approach, their key outcomes and challenges. DATA SOURCES: MEDLINE was searched for birth cohorts that have employed an exposomic approach. Study Selections Relevant studies in English language were selected and reviewed. RESULTS: The outcomes of birth ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
In this study, the relationship between ...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Research Source Type: research
Neto, M ário Batista Ciríaco / Silva-Souza, Kassia Paloma da / Maranhão, Valéria Fernandes / Botelho, Kátia Virginia Guerra / Heimer, Mônica Vilela / Dos Santos-Junior, Valdeci EliasPage 741 - 746Purpose: To verify the prevalence of developmental defects of enamel (DDE) in deciduous teeth and analyse the association with adverse events that occurred during pregnancy and early childhood.Materials and Methods: In a cross-sectional study, 152 children with an average age of 3.57 ± 1.25 years were examined according to the criteria established by the DDE index. A previously valid...
Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research
(N Engl J Med. 2020;382:574–575)
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Mother, Fetus, Neonate Source Type: research
Capsule summary: Our data support the role of early and late-pregnancy vitamin D sufficiency in attenuation of the risk of offspring asthma or/and recurrent wheeze in early childhood and the progression to active asthma at later childhood.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
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