p38 δ genetic ablation protects female mice from anthracycline cardiotoxicity.

CONCLUSIONS: p38d plays a crucial role in promoting DOX-induced cardiotoxicity in female mice by inhibiting autophagy. Therefore, p38d targeting could be a potential cardioprotective strategy in anthracycline chemotherapy. PMID: 32822209 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32822209?dopt=Abstract

Source: American Journal of Physiology. Heart and Circulatory Physiology - August 20, 2020 Category: Physiology Authors: George S, Kiss A, Obaid SN, Venegas A, Talapatra T, Wei C, Efimova T, Efimov IR Tags: Am J Physiol Heart Circ Physiol Source Type: research