Protective Effects of Astragalus membranaceus and Ligustrazine on Rat Brain Microvascular Endothelial Cell Injury after Oxygen-Glucose Depri-vation/Reoxygenation by Supressing the PKC δ/MARCKS Pathway.

CONCLUSIONS: The administration of Astragalus membranaceus and ligustrazine protected RBMECs against OGD/R-induced apoptosis. PKCδ/MARCKS and MMP9 expression were significantly increased after OGD/R stimulation, while Astragalus membranaceus and ligustrazine treatment evidently suppressed. Collectively,Astragalus membranaceus and ligustrazine play protective effects against OGD/R-induced injury in RBMECs through regulating PKCδ/MARCKS pathway to inhibit MMP9 activation. PMID: 32819229 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32819229?dopt=Abstract

Source: Combinatorial Chemistry and High Throughput Screening - August 17, 2020 Category: Chemistry Authors: Tang X, Wang H, Chen H, Sun S, Chen H, Pan R Tags: Comb Chem High Throughput Screen Source Type: research