Gargle lavage as a viable alternative to swab for detection of SARS-CoV-2.

Gargle lavage as a viable alternative to swab for detection of SARS-CoV-2.
Indian J Med Res. 2020 Aug 20;:
Authors: Mittal A, Gupta A, Kumar S, Surjit M, Singh B, Soneja M, Soni KD, Khan AR, Singh K, Naik S, Kumar A, Aggarwal R, Nischal N, Sinha S, Trikha A, Wig N
Abstract
Background & objectives: : Nasopharyngeal and oropharyngeal swab (NPS and OPS) collection is widely accepted as the preferred method for obtaining respiratory samples. However, it has certain disadvantages which may be overcome by gargling. The primary objective of this study was to assess agreement between gargle lavage and swab as an appropriate respiratory sample for the detection of SARS-CoV-2. The secondary objective was to assess the patient acceptability of the two sampling methods.
Methods: : It was a cross-sectional study done at a tertiary care hospital in New Delhi, India, on 50 confirmed COVID-19 patients. Paired swab (NPS and OPS) and gargle samples were taken within 72 h of their diagnosis. Samples were processed by reverse transcription-polymerase chain reaction (RT-PCR) for detection of SARS-CoV-2. Post-sample collection, a 10-point scale was administered to assess the level of discomfort with either of the collection methods.
Results: : All gargle samples were positive and comparable to their corresponding swab samples irrespective of the symptoms and duration of illness. The cycle threshold (C.
t: ) values for gargle sa...

Source: Indian J Med Res - August 19, 2020 Category: Research Authors: Mittal A, Gupta A, Kumar S, Surjit M, Singh B, Soneja M, Soni KD, Khan AR, Singh K, Naik S, Kumar A, Aggarwal R, Nischal N, Sinha S, Trikha A, Wig N Tags: Indian J Med Res Source Type: research