99mTc-gallic-gold nanoparticles as a new imaging platform for tumor targeting.
99mTc-gallic-gold nanoparticles as a new imaging platform for tumor targeting.
Appl Radiat Isot. 2020 Oct;164:109269
Authors: Sakr TM, El-Hashash MA, El-Mohty AA, Essa BM
Abstract
Early and accurate detection of tumor assists in identifying more effective therapies. Gold nanoparticles (GNPs) were synthesized by green synthesis method using gallic acid (GA) then characterized and labeled with technetium-99m. This new platform was biologically evaluated in both normal and solid tumor bearing mice. The in-vivo study of [99mTc]Tc-gallic-GNPs via both I.V. and I.T injecton showed a high accumulation in tumor site. As a result, [99mTc]Tc-gallic-GNPs can be afforded as a potential nano-platform for tumor imaging.
PMID: 32819507 [PubMed - in process]
Source: Applied Radiation and Isotopes - Category: Radiology Authors: Sakr TM, El-Hashash MA, El-Mohty AA, Essa BM Tags: Appl Radiat Isot Source Type: research