Influence of the particle size of gadolinium-loaded chitosan nanoparticles on their tumor-killing effect in neutron capture therapy in vitro.

Influence of the particle size of gadolinium-loaded chitosan nanoparticles on their tumor-killing effect in neutron capture therapy in vitro.
Appl Radiat Isot. 2020 Oct;164:109270
Authors: Andoh T, Nakatani Y, Suzuki M, Sakurai Y, Fujimoto T, Ichikawa H
Abstract
Neutron capture therapy using 157Gd (Gd-NCT) is currently under development as a cancer radiotherapy. Melanoma cells were treated with gadolinium-loaded chitosan nanoparticles (Gd-nanoCPs) for Gd-NCT. Smaller Gd-nanoCPs had higher Gd content and better cellular association of Gd and thereby made the tumor-killing effect more efficient in comparison to larger Gd-nanoCPs. This indicates that Gd-nanoCP size reduction is an efficient method for improving the cellular affinity of Gd-nanoCPs and for enhancing the tumor-killing effect of Gd-NCT.
PMID: 32819508 [PubMed - in process]

Source: Applied Radiation and Isotopes - August 22, 2020 Category: Radiology Authors: Andoh T, Nakatani Y, Suzuki M, Sakurai Y, Fujimoto T, Ichikawa H Tags: Appl Radiat Isot Source Type: research