Research Progress of Herbal Medicines on Drug Metabolizing Enzymes: Consideration Based on Toxicology.

Research Progress of Herbal Medicines on Drug Metabolizing Enzymes: Consideration Based on Toxicology. Curr Drug Metab. 2020 Aug 19;: Authors: Wang S, Li W, Yang J, Yang Z, Yang C, Jin H Abstract The clinical application of herbal medicines is increasing, but there is still a lack of comprehensive safety data and in-depth research into mechanisms of action.The composition of herbal medicines is complex, with each herb containing a variety of chemical components. Each of these components may affect the activity of metabolizing enzymes, which may lead to herb-drug interactions. It has been reported that the combined use of herbs and drugs can produce some unexpected interactions. Therefore, we have reviewed the progress of research on safety issues caused by the effects of herbs on metabolizing enzymes with reference to six categories of drugs, including antithrombotic drugs, non-steroidal anti-inflammatory drugs, antidiabetic drugs, statins lipid-lowering drugs, immuno suppressants and antineo plastic drugs. Under-standing the effects of herbs on the activity of metabolizing enzymes can avoid the toxicity and adverse drug reactions resulting from the co-administration of herbs and drugs, and help doctors to reduce the risk of prescription incompatibility. PMID: 32819254 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research