Cancers, Vol. 12, Pages 2362: Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives
Cancers, Vol. 12, Pages 2362: Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives
Cancers doi: 10.3390/cancers12092362
Authors:
Matías Chacón
Yanina Pfluger
Martín Angel
Federico Waisberg
Diego Enrico
Malignant melanoma represents the most aggressive type of skin cancer. Modern therapies, including targeted agents and immune checkpoint inhibitors, have changed the dismal prognosis that characterized this disease. However, most evidence was obtained by studying patients with frequent subtypes of cutaneous melanoma (CM). Consequently, there is an emerging need to understand the molecular basis and treatment approaches for unusual melanoma subtypes. Even a standardized definition of infrequent or rare melanoma is not clearly established. For that reason, we reviewed this challenging topic considering clinical and molecular perspectives, including uncommon CMs—not associated with classical V600E/K BRAF mutations—malignant mucosal and uveal melanomas, and some unusual independent entities, such as amelanotic, desmoplastic, or spitzoid melanomas. Finally, we collected information regarding melanomas from non-traditional primary sites, which emerge from locations as unique as meninges, dermis, lymph nodes, the esophagus, and breasts. The aim of this review is to summarize and highlight the main scientific evidence regarding rare melanomas, with a particular focus on treatment perspectives.
Source: Cancers - Category: Cancer & Oncology Authors: Mat ías Chacón Yanina Pfluger Mart ín Angel Federico Waisberg Diego Enrico Tags: Review Source Type: research
More News: Cancer | Cancer & Oncology | Esophagus Cancer | Eye Cancers | Melanoma | Men | Skin | Skin Cancer | Uveal Melanoma