Introduction of enzyme-responsivity in biomaterials to achieve dynamic reciprocity in cell-material interactions.

Introduction of enzyme-responsivity in biomaterials to achieve dynamic reciprocity in cell-material interactions. Biomacromolecules. 2020 Aug 19;: Authors: Brouns J, Dankers PYW Abstract Much effort has been made in the development of biomaterials that synthetically mimic the dynamics of the natural extracellular matrix in tissues. Most of these biomaterials specifically interact with cells, but lack the ability to adapt and truly communicate with the cellular environment. Communication between biomaterials and cells is achieved by the development of various materials with enzyme-responsive moieties, in order to respond to cellular cues. In this perspective, we discuss different enzyme-responsive systems, from surfaces to supramolecular assemblies. Additionally, we highlight their further prospects, in order to create, inspired by nature, fully autonomous adaptive biomaterials that display dynamic reciprocal behavior. This perspective shows new strategies for the development of biomaterials which may find broad utility in regenerative medicine applications, from scaffolds for tissue engineering to systems for controlled drug delivery. PMID: 32813514 [PubMed - as supplied by publisher]
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research