The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors

During the direct reprogramming of fibroblasts to hepatocyte-like cells, Foxa3 acts as a pioneer factor, similar to Foxa1 and Foxa2, but leaves its binding site to interact and migrate with RNA polymerase II, thereby inducing the transcription of target genes.

Source: Molecular Cell - August 3, 2020 Category: Cytology Authors: Kenichi Horisawa, Miyako Udono, Kazuko Ueno, Yasuyuki Ohkawa, Masao Nagasaki, Sayaka Sekiya, Atsushi Suzuki Tags: Article Source Type: research