High Affinity Nanobodies Targeting B7-H3 (CD276) for Treating Solid Tumors

CD276 (also called B7-H3) is a pan-cancer antigen expressed in multiple solid tumors and an emerging cancer target. CD276 protein is overexpressed in pancreatic cancer, prostate cancer, breast cancer, colon cancer, lung cancer, and brain tumors (such as neuroblastoma) – making it an ideal target for cancer therapy. Investigators at the National Cancer Institute (NCI) have isolated a panel of anti-CD276 single domain antibodies (also known as nanobodies) from novel camel and rabbit single domain (VHH) libraries by phage display.  Nanobodies are the smallest known antigen-binding fragments of antibodies. Due to their small size, high solubility, thermal stability, refolding capacity, and relatively easy tissue penetration, they have great potential as medical applications and research tools. These antibodies can be used as either independent agents or targeting domains in recombinant immunotoxins (RITs), antibody-drug conjugates (ADCs), and chimeric antigen receptors (CARs). The CARs using the RWB12, RWC4 and RWG8 antibodies have shown potent killing in various CD276-expressing tumor cell models, strongly supporting that these candidates may be further developed as therapeutics.  The NCI seeks licensing and/or co-development research collaborations for CD276-targeting camel nanobodies.  IC: NCINIH Ref. No.: E-185-2019Advantages: Antibodies with high CD276 binding specificity should result in less non-specific cell killing (off-target toxicity) and lower pot...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research