Repetitive and Self-injurious Behaviors in Children with Cornelia de Lange Syndrome.

Repetitive and Self-injurious Behaviors in Children with Cornelia de Lange Syndrome. J Autism Dev Disord. 2020 Aug 18;: Authors: Srivastava S, Clark B, Landy-Schmitt C, Offermann EA, Kline AD, Wilkinson ST, Grados MA Abstract Cornelia de Lange syndrome (CdLS) is associated with repetitive and self-injurious behaviors (RBs, SIB). Evaluating children with CdLS, this study: (1) characterizes the spectrum of RBs; (2) characterizes the impact and severity of RBs including SIB; (3) describes how age and adaptive functioning relate to RBs including SIB. Fifty children (5-17 years) with CdLS were assessed with Children's Yale-Brown Obsessive Compulsive Scale Modified for PDD; Aberrant Behavior Checklist (ABC); Vineland Adaptive Behaviors Scales (VABS). All children had ≥ 1 type of RB; 44% had some form of SIB. 64% spent > 1 h/day displaying RBs. Lower VABS adaptive functioning was associated with higher stereotypy and SIB scores (ABC). In children with CdLS, RBs including SIB are common, impactful, and associated with lower adaptive functioning. PMID: 32809170 [PubMed - as supplied by publisher]
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research

Related Links:

Publication date: Available online 8 October 2020Source: Neurología (English Edition)Author(s): C. Peña-Salazar, M. López Cuiña, V. Chavarría, B. Robles Olmo
Source: Neurologia - Category: Neurology Source Type: research
Campbell Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by disruptions in social communication and behavioral flexibility. Both genetic and environmental factors contribute to ASD risk. Epidemiologic studies indicate that roadway vehicle exhaust and in utero exposure to diesel particulate matter (DPM) are associated with ASD. Using the Comparative Toxicogenomics Database (CTD), we identified genes connected to DPM exposure and ASD, extracted the known enhancers/promoters of the identified genes, and integrated this with Assay for Transposase Accessible Chromatin (ATAC-seq) data from DPM...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Publication date: Available online 8 October 2020Source: Stem Cell ResearchAuthor(s): Morad Kamand, Mirolyuba Ilieva, Sheena Louise Forsberg, Mads Thomassen, Åsa Fex Svenningsen, Morten Meyer, Tanja Maria Michel
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 8 October 2020Source: Journal of Psychiatric ResearchAuthor(s): Thomas D. Meram, Asadur Chowdury, Philip Easter, Tyler Attisha, Ellanya Kallabat, Gregory L. Hanna, Paul Arnold, David R. Rosenberg, Vaibhav A. Diwadkar
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including impaired social communication and restricted repetitive behavior. In addition, many affected individuals display metabolic imbalances, immune dysregulation, gastrointestinal (GI) dysfunction, and altered gut microbiome compositions.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research
NOCD, a Chicago startup specializing in the identification and treatment of obsessive compulsive disorder, raised a new round of funding as it works to expand its services across the U.S. The startup announced on Thursday that it raised $12 million in a Series A round led by Health Enterprise Partners. Previous investors 7Wire Ventures, Chicago Ventures and Hyde Park Angels also participated. The funding brings NOCD’s total funding to more than $17 million to date. Last year, th e startup raised…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
(Mary Ann Liebert, Inc./Genetic Engineering News) Ableist language is often used by autism researchers, which assumes that autistic people are " broken " or inferior to non-autistic people.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsDisrupted protein interactions identify gene sets involved in risk for ASD. Their gene expression during brain development and within cell types highlights how they relate to ASD.
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Although fMRI studies have produced considerable evidence for differences in the spatial connectivity of resting-state brain networks in persons with autism spectrum disorder (ASD) relative to typically developing (TD) peers, little is known about the temporal dynamics of these brain networks in ASD. The aim of this study was to examine the EEG microstate architecture in children with ASD as compared to TD at rest in two separate conditions – eyes-closed (EC) and eyes-open (EO). EEG microstate analysis was performed on resting-state data of 13 ASD and 13 TD children matched on age, gender, and IQ. We found that child...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Individuals with autism spectrum disorders (ASD) are impaired not only in social competencies but also in sensory perception, particularly olfaction. The olfactory ability of individuals with ASD has been examined in several psychophysical studies, but the results have been highly variable, which might be primarily due to methodological difficulties in the control of odor stimuli (e.g., the problem of lingering scents). In addition, the neural correlates of olfactory specificities in individuals with ASD remain largely unknown. To date, only one study has investigated this issue using functional magnetic resonance imaging ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
More News: Autism | Child Development | Children | Cornelia de Lange Syndrome | Obsessive Compulsive Disorder | Psychiatry | Study | Yale