High-Scatter Lymphocytes in the Blood of Erythrodermic Cutaneous T-Cell Lymphoma: Evidence for Large-Cell Transformation?

Publication date: September 2020Source: Clinical Lymphoma Myeloma and Leukemia, Volume 20, Issue 9Author(s): Eric C. Vonderheid, Jennifer Jakubowski, J. Steve Hou
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 18 September 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Pierluigi Porcu, Stacie Hudgens, Steven Horwitz, Pietro Quaglino, Richard Cowan, Larisa Geskin, Marie Beylot-Barry, Lysbeth Floden, Martine Bagot, Athanasios Tsianakas, Alison Moskowitz, Auris Huen, Brigitte Dreno, Stéphane Dalle, Dolores Caballero, Mollie Leoni, Stephen Dale, Fiona Herr, Madeleine Duvic
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: Available online 30 June 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Matthew R. Kudelka, Jeffrey M. Switchenko, Mary Jo Lechowicz, Natia Esiashvili, Christopher R. Flowers, Mohammad K. Khan, Pamela B. Allen
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: Available online 30 June 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Matthew R. Kudelka, Jeffrey M. Switchenko, Mary Jo Lechowicz, Natia Esiashvili, Christopher R. Flowers, Mohammad K. Khan, Pamela B. Allen
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
We assessed the impact of maintenance therapy following total skin electron beam therapy (TSEB) in 101 cutaneous T-cell lymphoma (CTCL) patients in a single-center retrospective analysis. Maintenance regimens included ultraviolet, nitrogen mustard, and systemic therapies. Any maintenance was associated with longer progression-free survival (PFS) compared to no maintenance, while ultraviolet-based maintenance improved both PFS and overall survival, supporting maintenance administration following TSEB in CTCL.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Maintenance therapy following total skin electron beam therapy (TSEB) has been proposed as a promising approach for patients suffering from cutaneous T-cell lymphoma (CTCL). However, prior studies have been mixed for an effect of maintenance on progression-free survival (PFS), with minimal evidence for an effect on overall survival (OS). We conducted a single-center retrospective analysis of 101 CTCL patients undergoing TSEB and found that pooled maintenance therapy improved PFS and that ultraviolet therapy, specifically, improved both PFS and OS. Our data support the use of maintenance therapy in CTCL.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
In this study, we describe the patient characteristics, treatments and outcomes of 17 tMF patients in COMPLETE: a multicenter, prospective US cohort study of peripheral T-cell lymphoma. Responses were observed with single agents, but survival remains poor. Novel treatment approaches are urgently needed to improve outcomes.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Publication date: Available online 4 May 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Eric C. Vonderheid, Jennifer Jakubowski, J. Steve Hou
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Increasing number of large cells in the peripheral blood of patients with erythrodermic cutaneous T-cell lymphoma may reflect large-cell transformation. We found that flow cytometry accurately detected high-scatter T lymphocytes in initial blood samples from 10 of 19 patients with S ézary syndrome, 1 of 13 patients with erythrodermic mycosis fungoides, and no patient with nonneoplastic inflammatory conditions. The presence of high-scatter lymphocytes suggests a poor prognosis even for patients with advanced disease.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Increasing number of large cells in the peripheral blood of E-CTCL patients may reflect large cell transformation. Using flow cytometry can accurately detect large cell population in E-CTCL patients (10 of 19 patients with SS, 1 of 13 patients with E-MF, and no patient with non-neoplastic conditions). Presence of HSLs connotes a poor prognosis even for patients with advanced disease.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Publication date: Available online 24 December 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): David B. Griffin, Tamar Hajar, Eric Simpson, Kevin P. White, Michi M. Shinohara
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
More News: Cancer & Oncology | Cutaneous T cell lymphoma | Leukemia | Lymphoma | Myeloma | T-cell Lymphoma