Targeting the DNA damage response for patients with lymphoma: preclinical and clinical evidences

The DNA damage response (DDR) is an integrated kinase-driven cellular network activated by both endogenous and exogenous DNA damage [1-3] and has a key role in maintaining genomic integrity. The main steps in DDR are DNA damage recognition and activation of intra-cellular signaling pathways, mainly through sequential phosphorylations, which lead to transient cell cycle arrest and activation of DNA repair pathways. The ultimate goal of the DDR is the survival of cells that have successfully repaired DNA lesions.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Anti-tumour Treatment Source Type: research