Src Family Kinases in the Central Nervous System ：Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain.

This article briefly reviews the recent advances uncovering the interplay of SFK with diverse membrane proteins and intracellular proteins in the CNS and the importance of SFK in the pathophysiology of migraine and neuropathic pain. Mechanisms underlying the role of SFK in these conditions and potential clinical applications of SFK inhibitors in neurological diseases are also summarised. We propose that SFK are the convergent point of signalling pathways in migraine and neuropathic pain and may constitute a promising therapeutic target for these diseases. PMID: 32798375 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32798375?dopt=Abstract

Source: Current Neuropharmacology - August 13, 2020 Category: Drugs & Pharmacology Authors: Nie L, Ye WR, Chen S, Chirchiglia D, Wang M Tags: Curr Neuropharmacol Source Type: research