Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells [Medical Sciences]

Medulloblastoma is the most common malignant brain tumor in children. Here we describe a medulloblastoma model using Induced pluripotent stem (iPS) cell-derived human neuroepithelial stem (NES) cells generated from a Gorlin syndrome patient carrying a germline mutation in the sonic hedgehog (SHH) receptor PTCH1. We found that Gorlin NES cells...

Source: Proceedings of the National Academy of Sciences - August 17, 2020 Category: Science Authors: Evelyn Susanto, Ana Marin Navarro, Leilei Zhou, Anders Sundstrom, Niek van Bree, Marina Stantic, Mohsen Moslem, Jignesh Tailor, Jonne Rietdiȷk, Veronica Zubillaga, Jens–Martin Hubner, Holger Weishaupt, Johanna Wolfsberger, Irina Alafuzoff, An Tags: Biological Sciences Source Type: research