Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE- ε4 in middle-age cognitively unimpaired individuals from the ALFA study.

CONCLUSION: To our knowledge, the present study is the first to show that carrying the BDNF Val66Met polymorphisms partially compensates the decreased on HSv associated with APOE-ε4 in middle-age cognitively unimpaired individuals.
PMID: 32804326 [PubMed - as supplied by publisher]

Source: Brain Structure and Function - August 16, 2020 Category: Neuroscience Authors: Vilor-Tejedor N, Operto G, Evans TE, Falcon C, Crous-Bou M, Minguillón C, Cacciaglia R, Milà-Alomà M, Grau-Rivera O, Suárez-Calvet M, Garrido-Martín D, Morán S, Esteller M, Adams HH, Molinuevo JL, Guigó R, Gispert JD, ALFA Study Tags: Brain Struct Funct Source Type: research