Deficiency of filamin A in endothelial cells impairs left ventricular remodelling after myocardial infarction

Conclusion
Deletion of FLNA in ECs aggravated MI-induced LV dysfunction and cardiac failure as a result of defective endothelial response and increased scar formation by impaired endothelial function and signalling.

Source: Cardiovascular Research - January 16, 2015 Category: Cardiology Authors: Bandaru, S., Gronros, J., Redfors, B., Cil, C., Pazooki, D., Salimi, R., Larsson, E., Zhou, A.-X., Omerovic, E., Akyurek, L. M. Tags: Cardiac biology and remodelling Source Type: research