Impaired P2X signalling pathways in renal microvascular myocytes in genetic hypertension

Conclusions
Our study unravels the cellular and molecular mechanisms of attenuation of P2XR-mediated preglomerular vasoconstriction that elevates glomerular susceptibility to harmful hypertensive pressures. This provides an important impetus towards understanding of the pathology of hypertensive renal injury.

Source: Cardiovascular Research - January 16, 2015 Category: Cardiology Authors: Gordienko, D., Povstyan, O., Sukhanova, K., Raphael, M., Harhun, M., Dyskina, Y., Lehen'kyi, V., Jama, A., Lu, Z.-L., Skryma, R., Prevarskaya, N. Tags: Integrative physiology and pathophysiology Source Type: research