Synthesis of biocompatible silver nanoparticles by a modified polyol method for theranostic applications: Studies on red blood cells, internalization ability and antibacterial activity.

Synthesis of biocompatible silver nanoparticles by a modified polyol method for theranostic applications: Studies on red blood cells, internalization ability and antibacterial activity. J Inorg Biochem. 2020 Aug 01;211:111177 Authors: Sofia NG, Nikos B, Elias S, Eleni EK Abstract Recently, there has been ongoing research in the field of nanotechnology and nanomedicine aiming at developing multifunctional biomaterials using noble metals. The unique properties of silver (Ag) are known from ancient times and thus are being explored for their behavior on the nano scale. Silver shows high antimicrobial activity against different microorganisms, while modification of the surface of its nanostructures can be useful in active targeting regarding cancer treatment. During the synthetic procedure, in order to obtain a more uniform sample of silver nanoparticles (Ag NPs) with spherical morphology, a stabilizer is essential. The stabilizers used not only control the progression of the reaction, but also increases the biocompatibility of the NPs. Thus, we managed to synthesize spherical and rod-like Ag NPs via a polyol method and stabilize them with polyvinylpyrrolidone (PVP). The resulted Ag NPs were characterized morphologically with Transmission Electron Microscopy (TEM) and further confirmed by their structural characterization (FT-IR, UV-Vis, Dynamic Light Scattering (DLS) and Zeta Potential). For their biocompatibility profile, we studied th...
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research