Potential Mechanism of Left Ventricular Spherical Remodeling: Association of Mitral Valve Complex-Myocardium Longitudinal Tissue Remodeling Mismatch.

Potential Mechanism of Left Ventricular Spherical Remodeling: Association of Mitral Valve Complex-Myocardium Longitudinal Tissue Remodeling Mismatch. Am J Physiol Heart Circ Physiol. 2020 Aug 14;: Authors: Nagata Y, Iwataki M, Nabeshima Y, Hei S, Onoue T, Hayashi A, Otani K, Tsuda Y, Araki M, Kim DH, Song JK, Hayashida A, Toki M, Yuasa T, Mizukami N, Nishimura Y, Levine R, Otsuji Y Abstract Since mitral valve (MV) complex (MVC) longitudinally bridges left ventricular (LV) base-end and its middle, insufficient MVC longitudinal tissue length (TL) elongation relative to whole LV myocardial longitudinal TL elongation could limit LV-base-longitudinal-TL elongation, leading to predominant LV-base-transverse-TL elongation, constituting LV spherical remodeling. In 30 patients with dilated cardiomyopathy (DCM), 30 with aortic regurgitation (AR), and 30 controls, LV sphericity, LV-apex- or base- transverse- and longitudinal-TL, MVC-longitudinal-TL and whole-LV-longitudinal-TL were measured by 3D echocardiography. Ratio of each measure vs. mean normal value (i.e., LV-apex-transverse-TL ratio) was considered to express the directional and regional tissue elongation. [LV-base-longitudinal-TL ratio/global-LV-TL ratio] and [MVC-longitudinal-TL ratio/whole-LV-longitudinal-TL ratio] were obtained as the degree of LV-base-longitudinal-TL or MVC-longitudinal-TL elongation relative to the whole LV elongation. LV-apex-transverse-, LV-apex-longitudinal- a...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research