Early- and late-endothelial progenitor cells are negatively associated with the severity of vascular status in controlled hypertensive patients.

Early- and late-endothelial progenitor cells are negatively associated with the severity of vascular status in controlled hypertensive patients. Am J Physiol Heart Circ Physiol. 2020 Aug 14;: Authors: de Cavanagh EAM, Gonzalez SA, Inserra F, Forcada PJ, Castellaro CE, Chiabaut-Svane JA, Obregón S, Casarini MJ, Kempny P, Kotliar C Abstract Patients presenting classical cardiovascular risk factors within acceptable or average value ranges often develop cardiovascular disease, suggesting that other risk factors need to be considered. Considering that endothelial progenitor cells (EPC) contribute to endothelial repair, we investigated whether EPC might be such a factor. We compared the ability of peripheral blood EPC to attach to extracellular matrix proteins, and to grow and function in culture, between controlled-hypertensive patients exhibiting Framingham scores (FS)<10% while displaying severe vascular impairment (intima-media thickness/diameter, carotid-femoral pulse wave velocity, brachial artery flow-mediated dilation, carotid and femoral atherosclerotic plaque presence) (Vulnerable group, N=30), and those with FS≥10% and scarce vascular changes (Protected group, N=30). In Protected patients early- and late-EPC, and early- and late-tunneling nanotube (TNT) numbers were significantly higher versus Vulnerable patients. Significant negative associations were found between vascular damage severity and early-EPC, late-EPC, or lat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research