Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B

ConclusionsHerein, we hypothesized that MSC-exo would have a direct beneficial effect on the behavioral autistic-like phenotype of the genetically modified Shank3B KO mouse model of autism. Taken together, our data indicate that intranasal treatment with MSC-exo improves the core ASD-like deficits of this mouse model of autism and therefore has the potential to treat ASD patients carrying the Shank3 mutation.
Source: Molecular Autism - Category: Molecular Biology Source Type: research