Effect of neoadjuvant chemotherapy on breast tissue composition: a longitudinal mammographic study with automated volumetric measurement

ConclusionsNAC affects breast tissue composition, reflected as reductions in BV, FGV, and BD. Mammography with automated volumetric measurement can capture quantitative changes in these breast tissue parameters during NAC.Key Points• Neoadjuvant chemotherapy (NAC) affects breast tissue composition with different patterns of reduction in breast volume, fibroglandular volume, and breast density.• Age, Volpara density grades, and NAC regimen were independent factors associated with breast density change between pre-treatment and post-treatment.• Mammography with automated volumetric measurement enables identification of longitudinal changes in breast tissue composition.
Source: European Radiology - Category: Radiology Source Type: research