Excessive Body Fat at a Young Age Increases the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis.

Excessive Body Fat at a Young Age Increases the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis. Nutr Cancer. 2020 Aug 14;:1-12 Authors: Lei X, Song S, Li X, Geng C, Wang C Abstract Overweight and obesity was considered as a risk factor for colorectal cancer (CRC), and CRC development may be due to exposure during one's youth. Metabolic syndrome and insulin resistance seem to play an important role in the underlying mechanisms. Even though several studies indicated the association between BMI at young age and CRC risks, an identified founding is still lacked. Therefore, we conducted a meta-analysis and a dose-response analysis to quantify the association between BMI at young age and CRC risks with relative accuracy. We searched the PubMed, Embase, Medline and Cochrane Library databases for articles published before Sep. 15, 2019. Fifteen articles with 2 520 091 participants were included. Risk for CRC was estimated using relative risks (RR) and 95% confidence intervals (CIs). Compared with individuals with normal weight, overweight and obese young adults had a significantly higher risk of CRC (relative risks (RR):18%, 95% CI:1.08, 1.28； RR:32%, 95% CI: 1.11, 1.56, respectively). However, this correlation may not exist for obese women (RR: 1.22, 95% CI: 0.99, 1.51); Overweight may not a risk factor for rectal cancer (RC) (RR: 1.12, 95% CI: 0.97, 1.29). In the dose-response analysis, we observed a linear relationship...
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research