Changes in the cerebrospinal fluid lipid profile following subarachnoid hemorrhage in a closed cranium model: Correlations to cerebral vasospasm, neuronal cell death and Interleukin-6 synthesis. A pilot study
Phospholipids and sphingolipids are cell membrane components, that participate in signaling events and regulate a wide variety of vital cellular processes. Sphingolipids are involved in ischemic stroke pathophysiology. Throughout cleavage of membrane sphingomyelin by sphingomyelinase in stroke patients, it results in increased Ceramide (Cer) levels in brain tissue. Different studies showed the evidence that sphingomyelinase with Cer production induces expression of interleukin (IL)-6 and have vasoconstrictive proprieties.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Davide Croci, Edin Nevzati, Carl Muroi, Salome Sch öpf, Thorsten Hornemann, Hans-Rudolf Widmer, Hiroki Danura, Javier Fandino, Serge Marbacher Source Type: research
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