Lipoprotein-based drug delivery.

Lipoprotein-based drug delivery.
Adv Drug Deliv Rev. 2020 Aug 10;:
Authors: Busatto S, Walker SA, Grayson W, Pham A, Tian M, Nesto N, Barklund J, Wolfram J
Abstract
Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.
PMID: 32791075 [PubMed - as supplied by publisher]

Source: Advanced Drug Delivery Reviews - August 9, 2020 Category: Drugs & Pharmacology Authors: Busatto S, Walker SA, Grayson W, Pham A, Tian M, Nesto N, Barklund J, Wolfram J Tags: Adv Drug Deliv Rev Source Type: research