The retrotransposition of L1 is involved in the reconsolidation of contextual fear memory in mice.

CONCLUSIONS: The retrotransposition of L1 participated in the reconsolidation of fear memory after the reactivation of fear memory , and with lamivudine treatment, spontaneous recovery was decreased with time after the recent and remote fear memory recall, which might provide more clues for understanding the roles of L1 in fear memory and the possible strategy for treating PTSD.
PMID: 32787766 [PubMed - as supplied by publisher]

Source: CNS and Neurological Disorders Drug Targets - August 11, 2020 Category: Drugs & Pharmacology Authors: Zhang WJ, Huang YQ, Fu A, Chen KZ, Li SJ, Zhang Q, Zou GJ, Liu Y, Su JZ, Zhou SF, Liu JW, Li F, Bi FF, Li CQ Tags: CNS Neurol Disord Drug Targets Source Type: research