Sequential Changes of NLRP3 Inflammasome Activation in Sepsis and its Relationship With Death

Conclusions: NLRP3 is activated in critically ill patients but this up-regulation is more intense in patients with sepsis. In sepsis, a sustained NLRP3 activation during the first week is protective and sepsis. An increased caspase-1 protein expression with reduced expression caspase-3 is the pattern observed in septic shock patients who survive.
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research