Inflammatory response of uric acid produced by Porphyromonas gingivalis gingipains

In this study, we demonstrate thatP. gingivalis gingipains play a role in THP ‐1 macrophage uric acid production by increasing the expression and activity of xanthine oxidoreductase. Uric acid sodium salt induces caspase‐1 activation, cell death, and the expression of proinflammatory cytokines, including IL‐1α, IL‐6, and IL‐8, in the human keratinocyte HOK‐16B ce ll line. Our results suggest that gingipain‐induced uric acid can mediate inflammation in periodontal tissue cells.
Source: Molecular Oral Microbiology - Category: Microbiology Authors: Tags: ORIGINAL ARTICLE Source Type: research