Two-hit wonders: The expanding universe of multitargeting epigenetic agents.

Two-hit wonders: The expanding universe of multitargeting epigenetic agents.
Curr Opin Chem Biol. 2020 Aug 09;57:135-154
Authors: de Lera AR, Ganesan A
Abstract
Multitargeting involves the application of molecules that are deliberately intended to bind to two or more unrelated cellular targets with high affinity. In epigenetic chemical biology and drug discovery, the rational design of multitargeting agents has evolved to a sophisticated level, and there are now five examples that have reached clinical trials. This review covers recent developments in the field and future prospects.
PMID: 32784072 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - August 8, 2020 Category: Biochemistry Authors: de Lera AR, Ganesan A Tags: Curr Opin Chem Biol Source Type: research