Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation [Gene Regulation]

In conclusion, RUNX1 up-regulates the expression of Runx2 and multiple bone-specific genes, and plays an indispensable role in bone formation and homeostasis in both trabecular and cortical bone. We propose that stimulating Runx1 activity may be useful in therapeutic approaches for managing some bone diseases such as osteoporosis.

Source: Journal of Biological Chemistry - August 13, 2020 Category: Chemistry Authors: Jun Tang, Jing Xie, Wei Chen, Chenyi Tang, Jinjin Wu, Yiping Wang, Xue-Dong Zhou, Hou-De Zhou, Yi-Ping Li Tags: Cell Biology Source Type: research