EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution

Conclusions
In families with MS, the EBNA-1 IgG gradient being the highest in patients with MS, intermediate in their siblings, and lowest in biologically unrelated spouses indicates a genetic contribution to EBNA-1 IgG levels that is only partially explained by HLA-DRB1*1501 carriership.

Source: Neurology Neuroimmunology and Neuroinflammation - August 12, 2020 Category: Neurology Authors: Mescheriakova, J. Y., van Nierop, G. P., van der Eijk, A. A., Kreft, K. L., Hintzen, R. Q. Tags: Article Source Type: research