Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol.

This study demonstrates that the nonspecific binding of these highly lipophilic compounds needs to be taken into account in order to obtain accurate estimates of rates of in vitro metabolism of these pyrethroids. While DLM is rapidly metabolised in vitro, the hepatocyte membrane does not appear to represent a barrier to the absorption and hence subsequent hepatic metabolism of this pyrethroid.
PMID: 32757971 [PubMed - as supplied by publisher]

Source: Xenobiotica - August 5, 2020 Category: Research Authors: Price RJ, Scott MP, Cantrill C, Higgins LG, Moreau M, Yoon M, Clewell HJ, Creek MR, Osimitz TG, Houston JB, Lake BG Tags: Xenobiotica Source Type: research