Blockade of spinal dopamine D1/D2 receptor suppresses activation of NMDA receptor through Gαq and Src kinase to attenuate chronic bone cancer pain

Publication date: Available online 13 August 2020Source: Journal of Advanced ResearchAuthor(s): Wen-Ling Dai, Yi-Ni Bao, Ji-Fa Fan, Bin Ma, Shan-Shan Li, Wan-Li Zhao, Bo-Yang Yu, Ji-Hua Liu
Source: Journal of Advanced Research - Category: Research Source Type: research

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Bone cancer pain (BCP) is one of the most common types of chronic cancer pain and its pathogenesis has not been fully understood. Long non-coding RNAs (lncRNAs) are new promising targets in the field of pain r...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Research Source Type: research
Cinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain especially cancer pain. The current study aimed to evaluate its antinocicept...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
In this study, the authors hypothesized that the endoplasmic reticulum stress triggered by inflammatory mediators contributed to pain development.Methods The authors used a male mouse model of bone cancer pain. The control mice were intrathecally injected with tumor necrosis factor- α (TNF-α) and lipopolysaccharide, the bone cancer pain mice were intrathecally injected with the endoplasmic reticulum stress inhibitors 4-PBA and GSK2606414. The nociceptive behaviors, endoplasmic reticulum stress markers, and inflammatory mediators were assessed.Results Increased expression of the p-RNA-dependent protein kinase-li...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
By SAURABH JHA, MD Slumdog TB No one knows who gave Rahul Roy tuberculosis. Roy’s charmed life as a successful trader involved traveling in his Mercedes C class between his apartment on the plush Nepean Sea Road in South Mumbai and offices in Bombay Stock Exchange. He cared little for Mumbai’s weather. He seldom rolled down his car windows – his ambient atmosphere, optimized for his comfort, rarely changed. Historically TB, or “consumption” as it was known, was a Bohemian malady; the chronic suffering produced a rhapsody which produced fine art. TB was fashionable in Victorian Britain...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Health Tech Saurabh Jha TB tuberculosis Source Type: blogs
In conclusion, inhibition of spinal glia by XPro1595 may have utility in the treatment of bone cancer-induced neuroinflammation, and our results further implicate XPro1595 as a new promising therapeutic agent for BCP. PMID: 31002915 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
Zhong-Yan Zhou1,2†, Wai-Rong Zhao1†, Wen-Ting Shi1†, Ying Xiao1, Zi-Lin Ma1, Jin-Gui Xue3, Lun-Qing Zhang4, Qing Ye1, Xin-Lin Chen1* and Jing-Yi Tang1,5* 1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China 2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China 3Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China 4Faculty of Health Sciences, University of Macau, Macau, China 5Cardiac Rehabilitation Center of Longhua Hospital, Shanghai Univers...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 6 July 2018Source: Pharmacological ResearchAuthor(s): Ya-Qun Zhou, Dai-Qiang Liu, Shu-Ping Chen, Jia Sun, Xiao-Mei Wang, Yu-Ke Tian, Wei Wu, Da-Wei YeAbstractChronic pain remains to be a clinical challenge due to insufficient therapeutic strategies. Minocycline is a member of the tetracycline class of antibiotics, which has been used in clinic for decades. It is frequently reported that minocycline may has many non-antibiotic properties, among which is its anti-nociceptive effect. The results from our lab and others suggest that minocycline exerts strong analgesic effect in in animal mode...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
This study evaluated its antihypersensitivity activity in the rat models of neuropathic and cancer pains and explored its underlying mechanisms. Subcutaneous injection of cumulative doses of lappaconitine produced dose-dependent mechanical antiallodynia and thermal antihyperalgesia in spina l nerve ligation-induced neuropathic rats. The cumulative dose–response analysis exhibited theirEmax values of 53.3 and 58.3% MPE, and ED50 values of 1.1 and 1.6  mg/kg. Single intrathecal lappaconitine dose in neuropathy also dose- and time-dependently blocked mechanical allodynia, with anEmax of 66.1% MPE and an ED50 of 0.8...
Source: Psychopharmacology - Category: Psychiatry Source Type: research
In conclusion, these results suggested that l‐CDL attenuates TCI induced bone cancer pain through simultaneously inhibiting the NMDA and mGlu1/5 receptors and the downstream PKC γ, ERK1/2 signaling pathways in the spinal cord. This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
Abstract Chronic pain is among the most disabling and costly disorders, with prevalence ranging from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory due to our poor understanding of its mechanisms. Thus, novel therapeutic targets need to be found in order to improve these patients' quality of life. PI3K and its downstream Akt are widely expressed in the spinal cord, particularly in the laminae I-IV of the dorsal horn, where nociceptive C and Aδ fibers of primary afferents principally terminate. Recent studies have demonstrated their critical roles in the development an...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
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