FDA accepts application for Xolair (omalizumab) prefilled syringe for self-administration across all indications
Basel, 13 August 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the US Food and Drug Administration (FDA) accepted the company ’s supplemental Biologics License Application (sBLA) for a new self-administration option for Xolair® (omalizumab) across all approved US indications. If approved, Xolair prefilled syringe would become available for either self-administration by select patients or administration by their caregivers. A decision on approval is anticipated by Q1 2021. In the US, Xolair is currently approved for administration by a healthcare provider in a healthcare setting, and is the only approved biologic designed to target and block immunoglobulin E (IgE) for the treatment of patients with moderate to severe persistent allergic asthma and chronic idiopathic urticaria (CIU).
CONCLUSION: In CSU, the prevalence of self-reported drug allergies was higher than the general population. Drug allergy associated with older age, white race and higher BMI while multiple drug allergy also associated with asthma. These CSU sub-populations should be studied to avoid the potential for morbidity associated with less efficacious and more costly drugs. PMID: 33006537 [PubMed - as supplied by publisher]
CONCLUSION: Atopic disorders, previously recognized as predictors of poor sleep, are associated with COPCs after accounting for sleep problems. PMID: 32975542 [PubMed - as supplied by publisher]
Abstract Anaphylaxis is a life-threatening systemic reaction, normally occurring within one to two hours of exposure to an allergen. The incidence of anaphylaxis in the United States is 2.1 per 1,000 person-years. Most anaphylactic reactions occur outside the hospital setting. Urticaria, difficulty breathing, and mucosal swelling are the most common symptoms of anaphylaxis. The most common triggers are medications, stinging insect venoms, and foods; however, unidentified triggers occur in up to one-fifth of cases. Coexisting asthma, mast cell disorders, older age, underlying cardiovascular disease, peanut and tree...
Discussion There are 8 common foods which compromise 90% of food allergens with those being peanuts, soybeans, cow’s milk, eggs, fish, crustacean/shellfish, wheat and tree nuts. Some people believe that lupin (a legume) is 9th. Legumes belong to the Fabaceae family. They provide protein, fat, vitamins other essential nutrients and therefore are used in the human diet throughout the world. “[A]llergenicity due to consumption of legumes in decreasing order may be peanut, soybean, lentil, chickpea, pea, mung bean and red gram.” Other common legumes include alfalfa, clovers, beans, lupins, mesquite, carob...
CONCLUSION: Performing an open PT (without previous tests) in two steps in patients with low-risk drug reactions is safe. However, every case must be analized individually in terms of risk/benefit ratio. PMID: 32896639 [PubMed - as supplied by publisher]
AbstractPurpose of ReviewThis paper purports to review recent relevant publications on the efficacy of traditional Chinese medicine in treating allergic diseases, to illustrate the pertinent mechanisms of action of TCM, and to explore the possible role of TCM in the management of allergic diseases in the foreseeable future. As TCM embodies multiple treatment modalities, only the most popular two, namely CHM (Chinese herbal medicine) and acupuncture, were discussed. Publicat ions, especially reviews involving randomized controlled trials (RCTs) on the use of TCM on allergic diseases, published up to June 201...
Conclusions: The ELR and PLR may be useful in differentiating various types of immediate hypersensitivity to NSAIDs. Moreover, the ELR may be helpful in differentiating patients with bronchial asthma with and without NSAID hypersensitivity and PLR in differentiating patients with chronic spontaneous urticaria from NECD.Int Arch Allergy Immunol
The pandemic of coronavirus disease 2019 (COVID-19) has caused substantially adverse effects on health and economy at both individual and societal levels. It was estimated that the worldwide unemployment rate might increase from 4.9% to 5.6% owing to the pandemic.1 Decades of research have accumulated evidence on the adverse impacts of unemployment on poverty-related health outcomes and mental illness such as stress and anxiety.2 Interestingly, it has been well established that allergic diseases are associated with higher socioeconomic status (SES).
PMID: 32818594 [PubMed - as supplied by publisher]
The pandemic of coronavirus disease 2019 (COVID-19) has caused substantially adverse effects on health and economy at both individual and societal levels. It was estimated that the worldwide unemployment rate might increase from 4.9% to 5.6% owing to the pandemic.1 Decades of research have accumulated evidence on the adverse impacts of unemployment on poverty-related health outcomes and mental illness, such as stress and anxiety.2 Interestingly, it has been well established that allergic diseases are associated with higher socioeconomic status (SES).