MerTK negatively regulates Staphylococcus aureus induced inflammatory response via SOCS1/SOCS3 and Mal.

CONCLUSION: Collectively, these findings indicate the important role of MerTK in self-regulatory resolution of S. aureus-induced inflammatory pathways and cytokines through intrinsic SOCS1 and SOCS3 repressed feedback on TLR2, TLR6 both in vivo and in vitro.
PMID: 32747017 [PubMed - in process]

Source: Immunobiology - June 30, 2020 Category: Allergy & Immunology Authors: Zahoor A, Yang C, Yang Y, Akhtar M, Umar T, Khan MA, Ahmad S, Deng G, Guo MY Tags: Immunobiology Source Type: research