In vitro characterization of granulocyte-colony stimulating factor (G-CSF) production by dendritic cells and macrophages during Streptococcus suis infection.

In conclusion, this study demonstrated for the first time that S. suis induces G-CSF production in vivo and DCs and macrophages are key cellular sources of this cytokine mediator, mainly via the binding of lipoproteins to TLR2. The CPS significantly reduced this activation, confirming the powerful role of this component in S. suis virulence. As such, this study contributes to better understand how DCs and macrophages produce G-CSF in response to S. suis, and potentially to other streptococci. PMID: 32747024 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32747024?dopt=Abstract

Source: Immunobiology - June 30, 2020 Category: Allergy & Immunology Authors: Bleuzé M, Auger JP, Lavagna A, Gisch N, Gottschalk M, Segura M Tags: Immunobiology Source Type: research