Immunosuppressive role of CD11b+CD33+HLA ‐DR− myeloid‐derived suppressor cells‐like blast subpopulation in acute myeloid leukemia

ConclusionWe demonstrated that MDSC ‐like blasts drive AML‐specific immune‐escape mechanisms by suppressing T cell proliferation and restoring T cell‐suppressed NB4 cell proliferation, with clinically higher fractions of MDSC‐like blasts at diagnosis resulting in poor prognosis.

Source: Cancer Medicine - August 10, 2020 Category: Cancer & Oncology Authors: Shin Young Hyun, Eun Jung Na, Ji Eun Jang, Haerim Chung, Soo Jeong Kim, Jin Seok Kim, Jee Hyun Kong, Kwang Yong Shim, Jong In Lee, Yoo Hong Min, June ‐Won Cheong Tags: ORIGINAL RESEARCH Source Type: research