Novel imprint cytological classification is correlated with tumor spread through air spaces in lung adenocarcinoma

The concept of spread through air spaces (STAS) was introduced in the 2015 World Health Organization Classification of non-small cell lung cancer. STAS was shown to be a prognostic factor for poor outcomes after sublobar resection in patients with lung cancer [1,2]; therefore, intraoperative evaluation of the presence of STAS is considered to be important, especially for intentional limited resection of small pulmonary nodules under 2  cm in size. However, diagnosis based on the findings of intraoperative frozen section analysis, the most common method of histological evaluation of tumors, is reported to be difficult in the presence of STAS [3,4].

Source: Lung Cancer - August 10, 2020 Category: Cancer & Oncology Authors: Toru Kimura, Harumi Nakamura, Akiisa Omura, Akihiro Ike, Takashi Hiroshima, Tomohiro Maniwa, Keiichiro Honma, Masahiko Higashiyama, Jiro Okami Source Type: research