BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk: A cohort study

An association between BRCA pathogenic variants and an increased endometrial cancer risk, specifically serous-like endometrial cancer, has been postulated but remains unproven, particularly for BRCA2 carriers. Mechanistic evidence is lacking, and any link may be related to tamoxifen exposure or testing bias. Hysterectomy during risk-reducing bilateral salpingo-oophorectomy is, therefore, of uncertain benefit. Data from a large, prospective cohort will be informative.

Source: European Journal of Cancer - July 18, 2020 Category: Cancer & Oncology Authors: Sarah J. Kitson, Cemsel Bafligil, Neil A.J. Ryan, Fiona Lalloo, Emma R. Woodward, Richard D. Clayton, Richard J. Edmondson, James Bolton, Emma J. Crosbie, D. Gareth Evans Tags: Original Research Source Type: research