Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

A recent study (Sulkowski et  al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

Source: Molecular Cell - August 5, 2020 Category: Cytology Authors: Milan R. Savani, Kalil G. Abdullah, Samuel K. McBrayer Tags: Spotlight Source Type: research