Unwinding the Role of FACT in Cas9-based Genome Editing

In a recent issue of Molecular Cell, Wang et  al. (2020) employ unbiased proteomics approaches and live-cell imaging to reveal a key role for the histone chaperone complex FACT (SPT16 and SSRP1) in governing Cas9 turnover at the DNA target site during genome and epigenome editing.

Source: Molecular Cell - August 5, 2020 Category: Cytology Authors: Brian D. Cosgrove, Charles A. Gersbach Tags: Preview Source Type: research