Sleep problems and mental health difficulties in older adults who endorse high autistic traits
Publication date: September 2020Source: Research in Autism Spectrum Disorders, Volume 77Author(s): Gavin R. Stewart, Anne Corbett, Clive Ballard, Byron Creese, Dag Aarsland, Adam Hampshire, Rebecca A. Charlton, Francesca Happé
Conditions: Insomnia Chronic; Autism Spectrum Disorder Interventions: Behavioral: In-Person CBT for insomnia in children with autism; Behavioral: Remote CBT for insomnia in children with autism; Behavioral: Remote sleep hygiene and related education (SHARE) for insomnia in children with autism Sponsors: University of Missouri-Columbia; United States Department of Defense Not yet recruiting
Conditions: Autism; Autism Spectrum Disorder; Sleep Intervention: Behavioral: Behavioral treatment for sleep difficulties Sponsor: Soroka University Medical Center Not yet recruiting
BackgroundAutism spectrum disorder (ASD) is a type of neurodevelopmental disease that is frequently accompanied by sleep disorder. Herein, we investigated changes in the gut microbiota and its metabolites correlated with core symptoms and sleep problems in children with ASD.MethodsOne hundred and twenty children diagnosed with ASD based on Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria were enrolled in our study. The Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Childhood Autism Rating Scale (CARS) were used to assess autism symptoms, and the Children Sleep Habits Questionn...
In this study, we examined the impact of exposure to dim light at night (DLaN, 5 lx) in a model of ASD: the contactin associated protein-like 2 knock out (Cntnap2 KO) mice. DLaN was sufficient to disrupt locomotor activity rhythms, exacerbate the excessive grooming and diminish the social preference in Cntnap2 mutant mice. On a molecular level, DLaN altered the phase and amplitude of PER2::LUC rhythms in a tissue-specific manner in vitro. Daily treatment with melatonin reduced the excessive grooming of the mutant mice to wild-type levels and improved activity rhythms. Our findings suggest that common circadian disruptors...
ConclusionsResults from this TOSCA research project in an independent international data set showed that the combination of cluster analysis and factor analysis may be able to identify clinically meaningful natural TAND clusters. Findings were remarkably similar to those identified in the earlier feasibility study, supporting the potential robustness of these natural TAND clusters. Further steps should include examination of larger samples, investigation of internal consistency, and evaluation of the robustness of the proposed natural clusters.