A Vectorial, ER-Mitochondria Link to Energy Homeostasis in the Vascular Endothelium.

A Vectorial, ER-Mitochondria Link to Energy Homeostasis in the Vascular Endothelium.
Cell Metab. 2020 Aug 04;32(2):150-152
Authors: Boutagy NE, Fowler JW, Sessa WC
Abstract
The precise mechanisms of free fatty acid (FFA) uptake in the vascular endothelium are unclear. In this issue of Cell Metabolism, Ibrahim et al. (2020) discover that FFA uptake is partially mediated by a vectorial, ER-mitochondria link, in which mitochondrial ATP production is locally used for the acyl-CoA synthetase activity of the ER-located fatty acid transport protein 4.
PMID: 32755606 [PubMed - in process]

Source: Cell Metabolism - August 3, 2020 Category: Cytology Authors: Boutagy NE, Fowler JW, Sessa WC Tags: Cell Metab Source Type: research