Linking Matrix Rigidity with EMT and Cancer Invasion.

Linking Matrix Rigidity with EMT and Cancer Invasion.
Dev Cell. 2020 Aug 10;54(3):293-295
Authors: Ros M, Sala M, Saltel F
Abstract
The extracellular matrix (ECM) plays a major role in cancer progression through its increased deposition and alignment. In this issue of Developmental Cell, Fattet et al. reveal a pathway in which ECM stiffness promotes EPHA2/LYN complex activation, leading to TWIST1 nuclear localization and triggering EMT in breast cancer.
PMID: 32781020 [PubMed - in process]

Source: Developmental Cell - August 9, 2020 Category: Cytology Authors: Ros M, Sala M, Saltel F Tags: Dev Cell Source Type: research