Molecules, Vol. 25, Pages 3683: Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach

Molecules, Vol. 25, Pages 3683: Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach Molecules doi: 10.3390/molecules25163683 Authors: Chinedu P Anokwuru Sidonie Tankeu Sandy van Vuuren Alvaro Viljoen Isaiah D. I Ramaite Orazio Taglialatela-Scafati Sandra Combrinck Terminalia sericea Burch. ex. DC. (Combretaceae) is a popular remedy for the treatment of infectious diseases. It is widely prescribed by traditional healers and sold at informal markets and may be a good candidate for commercialisation. For this to be realised, a thorough phytochemical and bioactivity profile is required to identify constituents that may be associated with the antibacterial activity and hence the quality of raw materials and consumer products. The aim of this study was to explore the phytochemistry and identify the antibacterial constituents of T. sericea root bark, using a metabolomic approach. The chemical profiles and antibacterial activities of 42 root bark samples collected from three districts in the Limpopo Province, South Africa, were evaluated. Dichloromethane:methanol (1:1) extracts were analysed using ultraperformance liquid chromatography (UPLC)-mass spectrometry (MS), and chemometric models were constructed from the aligned data. The extracts were tested against Bacillus cereus (ATCC 11778), Staphylococcus epidermidis (ATCC 12223), Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 8739), Klebsiella pneumonia...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research