tDCS and Cognitive Training for Mild Cognitive Impairment and Alzheimer's Dementia

Conditions:   Alzheimer Disease;   Mild Cognitive Impairment Interventions:   Device: Active Transcranial Direct Current Stimulation (tDCS);   Device: Sham Transcranial Direct Current Stimulation (tDCS) Sponsor:   Minneapolis Veterans Affairs Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Since the coronavirus (Covid-19) lockdown on 23rd March 2020, this investigation found family and friends have spent an extra 92 million hours caring for loved ones with dementia, due to the double impact of lockdown making dementia symptoms worse, and the chronically underfunded social care system leaving them nowhere else to turn. It states that the government must fix social care now, learning lessons to avoid further winter tragedy, as dementia carers struggle with depression, insomnia and exhaustion.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Conclusions: Contrary to our hypothesis, we observed no improvement of gait parameters as assessed by SARA and GAIT ­Rite®, but coordination abilities were improved. Rivastigmine was well tolerated, but known side effects of rivastigmine, such as deterioration of asthma, may appear. Further trials in larger cohorts are needed to confirm our findings.Neurodegener Dis
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research
ConclusionsNPS of dementia during COVID-19 appear to arise from social restrictions occurring as a consequence of the pandemic. Implementation of caregiver support and the presence of skilled nursing home staff are required to restore social interaction and adjust technological support to the patients’ needs.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In the past decade, several groups have reported that microRNAs (miRNAs) can participate in the regulation of tau protein at different levels, including its expression, alternative splicing, phosphorylation, and aggregation. These observations are significant, since the abnormal regulation and deposition of tau is associated with nearly 30 neurodegenerative disorders. Interestingly, miRNA profiles go awry in tauopathies such as Alzheimer's disease, progressive supranuclear palsy, and frontotemporal dementia. Understanding the role and impact of miRNAs on tau biology could therefore provide important insights into disease r...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Kerrin Kuhn today is the executive director of the Alzheimer ’s&Dementia Resource Center (ADRC), but when she was taking care of her mother, who suffered from Alzheimer ’s, Kuhn had no idea the nonprofit was in the same metro where she lived.  Kuhn’s mother died 6 years ago, and it’s only after joining the Altamonte Springs-based organization that Kuhn realized how it could have helped her and her family. That realization makes her all the more passionate t o help the Central Floridians…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
miR-149-5p inhibition reduces Alzheimer's disease β-amyloid generation in 293/APPsw cells by upregulating H4K16ac via KAT8. Exp Ther Med. 2020 Nov;20(5):88 Authors: Chen F, Chen H, Jia Y, Lu H, Tan Q, Zhou X Abstract Alzheimer's disease (AD), the leading cause of age-related dementia, is characterized by abnormal β-amyloid accumulation. During learning, memory formation and consolidation, increased levels of histone H3 and H4 acetylation are observed. The present study reported significantly decreased level of H4K16ac in the plasma of patients with AD compared with healthy subjects via wester...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
This article reports on two online studies. In Study 1, 248 participants rated statements about dementia according to their threat to well-being. In Study 2, 99 participants (all students at the University of the West of England) completed the emerging scale (the Threat of Dementia Scale or ToDS). We validated this by examining its associations with conceptually related measures, including the revised Fraboni Scale of Ageism and the Fear of Alzheimer's Disease Scale. Study 1 yielded 13 statements that were highly intercorrelated and comprised a single factor. In Study 2, the ToDS demonstrated good construct validity and ac...
Source: International Journal of Aging and Human Development - Category: Geriatrics Tags: Int J Aging Hum Dev Source Type: research
Authors: Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC Abstract OBJECTIVE: Recent clinical trials targeting amyloid beta (Aβ) and tau in Alzheimer's disease (AD) have yet to demonstrate efficacy. Reviewing the hypotheses for AD pathogenesis and defining possible links between them may enhance insights into both upstream initiating events and downstream mechanisms, thereby promoting discovery of novel treatments. Evidence that in Down syndrome (DS), a population markedly predisposed to develop early onset AD, increased APP gene dose is necessary for both AD neuropat...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Amyloid beta (A β) accumulation may predispose some older adults to develop depressive episodes.1 In cognitively intact older adults, greater Aβ burden is cross-sectionally and longitudinally associated with greater depressive symptoms.2,3 In turn, cortical amyloid and depressive symptoms may interact to influenc e cognitive decline.4,5 Late-life depression (LLD) in the absence of dementia is associated with a higher plasma Aβ40:Aβ42 ratio,6 similar to what is seen in Alzheimer's disease (AD) and also an increased risk for cognitive decline and developing AD.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
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