Diffusion and perfusion MRI may predict EGFR amplification and the TERT promoter mutation status of IDH-wildtype lower-grade gliomas

ConclusionThis exploratory pilot study shows that lower ADC values may be useful for prediction of EGFR amplification, whereas higherVp values may be useful for prediction of the TERTp mutation status of IDHwt LGGs.Key Points•EGFR amplification and TERTp mutation are key molecular markers that predict an aggressive clinical course of IDHwt LGGs.•EGFR-amplified tumors showed lower ADC values than EGFR-non-amplified tumors, suggesting higher cellularity.•TERTp mutant tumors showed a higher plasma volume fraction than TERTp wildtype tumors, suggesting higher vascular proliferation and tumor angiogenesis.
Source: European Radiology - Category: Radiology Source Type: research